The Laboratory of Clinical Chemistry at the Zürich University of Applied Sciences is seeking a highly motivated Postdoctoral Researcher in the field of Mass Spectrometry, Proteomics, Biomarker Discovery, and Protein Biochemistry.

School: Life Sciences und Facility Management

Starting date: Review of applications for this SNF funded position will begin immediately and continue until the position is filled

Your role

This position offers a unique opportunity to conduct innovative research in proteomics and biomarker discovery, with a focus on integrating biochemical workflows with advanced mass spectrometry technologies to discover new disease specific biomarkers and potential drug targets. Your primary responsibilities:

• Leveraging experience with advanced LC-MS/MS systems (e.g., Q-TOF, Orbitrap, etc) and adapting methodologies to the research objectives.
• Designing and establishing cutting-edge workflows and conducting discovery and targeted proteomics experiments using advanced techniques such as, data-independent acquisition (DIA), label-free quantification (LFQ), or isotopic labeling to achieve comprehensive proteome coverage and precise quantitation of biomolecules.
• Analyzing complex proteomics datasets using state-of-the-art data analysis tools and interpreting results in a biological context.
• Establishing and implementing biochemical workflows, including protein purification, pull-down assays, and immunoprecipitation (IP), for studying protein interactions and functional characterization.
• Development of chemoproteomics workflows by using activity-based probes for targeting and profiling active proteins and integrating this data with conventional proteomics approaches for biomarker discovery and functional studies.
• Handling diverse human biological samples, including plasma, serum, and tissues.
• Supporting the development of cellular models for functional studies.
• Working independently while actively collaborating with group members on shared projects, publish manuscripts in peer-reviewed journals, assist in application for third-party funding and present findings at lab meetings and international conferences.
• Supervise junior staff, and support teaching activities of students within the institute.

Your profile

• A Ph.D. In Biochemistry, Chemical Biology, or a related field.
• A strong publication record demonstrating proficiency in advanced mass spectrometry technologies and proteomics workflows.
• Hands-on experience with high-resolution LC-MS/MS systems (e.g., Q-TOF or Orbitrap) and their applications in complex biological systems and familiarity with sample preparation techniques for proteomics, including protein extraction, digestion, and fractionation.
• Expertise in proteomics data analysis using state of the art software.
• Competence in protein biochemistry, performing biochemical assays and workflows and working with human clinical samples (Serum, Plasma, tissues, etc).
• Additional experience in working with chemoproteomics workflows or expertise in combining limited proteolysis with mass spectrometry will be given a special consideration.
• Experience in cell biology or cell culturing techniques (2D and 3D) techniques is considered a plus.

This is what we stand for

Zurich University of Applied Sciences ZHAW

ZHAW is committed to gender-mixed and diverse teams in order to promote equality, diversity and innovation.

What you can expect

We offer working conditions and terms of employment commensurate with higher education institutions and actively promote personal development for staff in leadership and non-leadership positions. A detailed description of advantages and benefits can be found at

Working at the ZHAW